Protein Kinase C Controls the Priming Step of Regulated Exocytosis in Adrenal Chromaffin Cells

@article{Misonou1998ProteinKC,
  title={Protein Kinase C Controls the Priming Step of Regulated Exocytosis in Adrenal Chromaffin Cells},
  author={Hiroaki Misonou and Mica Ohara-Imaizumi and Takeshi Murakami and Masakazu Kawasaki and Ken Ikeda and Takeshi Wakai and Konosuke Kumakura},
  journal={Cellular and Molecular Neurobiology},
  year={1998},
  volume={18},
  pages={379-390}
}
1. To investigate the mechanism whereby protein kinase C enhances secretory function in adrenal chromaffin cells, we examined the effects of 12-O-tetradecanoylphorbor-13-acetate (TPA) on Ca2+-induced catecholamine release from digitonin-permeabilized cells, resolving the release into a MgATP-dependent priming step and a MgATP-indepen-dent Ca2+-triggered step. Treatment with TPA selectively potentiated the priming activityof MgATP, with little increase in the MgATP-independent release. The… CONTINUE READING

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