Protein Kinase C (PKC) Activity Regulates Functional Effects of Kvβ1.3 Subunit on KV1.5 Channels

@article{David2012ProteinKC,
  title={Protein Kinase C (PKC) Activity Regulates Functional Effects of Kv$\beta$1.3 Subunit on KV1.5 Channels},
  author={M. David and A. Macias and Cristina Moreno and {\'A}. Prieto and Ram{\'o}n Mart{\'i}nez-M{\'a}rmol and R. Vicente and T. Gonzalez and A. Felipe and M. Tamkun and C. Valenzuela},
  journal={The Journal of Biological Chemistry},
  year={2012},
  volume={287},
  pages={21416 - 21428}
}
Background: Kvβ1.3 fast inactivation conferred onto Kv1.5 is PKC-dependent. Results: PKC inhibition shifts Kvβ1.3-induced inactivation curve without altering Kv1.5-Kvβ1.3 interaction. A Kv1.5 channelosome is characterized. Conclusion: Kv1.5 channelosome is composed of several PKC isoforms (βI, βII, and θ), Kvβ1.3 and RACK1 in HEK293 and in rat ventricular cells. Significance: This is the first evidence of a cardiac Kv1.5-Kvβ1.3-RACK1-PKC macromolecular complex. Kv1.5 channels are the primary… Expand
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