Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.

@article{SnchezFernndez2016ProteinKC,
  title={Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.},
  author={Guzm{\'a}n S{\'a}nchez-Fern{\'a}ndez and Sof{\'i}a Cabezudo and {\'A}lvaro Caballero and Carlota Garc{\'i}a-Hoz and Gregory G Tall and Javier Klett and Stephen W. Michnick and Federico Mayor and Catalina Ribas},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 18},
  pages={9513-25}
}
Heterotrimeric G proteins play an essential role in the initiation of G protein-coupled receptor (GPCR) signaling through specific interactions with a variety of cellular effectors. We have recently reported that GPCR activation promotes a direct interaction between Gαq and protein kinase C ζ (PKCζ), leading to the stimulation of the ERK5 pathway independent of the canonical effector PLCβ. We report herein that the activation-dependent Gαq/PKCζ complex involves the basic PB1-type II domain of… CONTINUE READING

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