Protein Kinase A Binds and Activates Heat Shock Factor 1

  title={Protein Kinase A Binds and Activates Heat Shock Factor 1},
  author={Ayesha Murshid and Shiuh-Dih Chou and T. Prince and Yue Zhang and A. C. Bharti and Stuart K. Calderwood},
  booktitle={PloS one},
BACKGROUND Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli. We have studied such regulation of Heat Shock Factor 1 (HSF1), a key protein in control of the heat shock response, and a participant in carcinogenisis, neurological health and aging. As the mechanisms involved in the intracellular regulation of HSF1 in good health and its dysregulation in disease are still incomplete we are… CONTINUE READING
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