Protein Kinase A Activity at the Endoplasmic Reticulum Surface Is Responsible for Augmentation of Human ether-a-go-go-related Gene Product (HERG)*

@article{Sroubek2011ProteinKA,
  title={Protein Kinase A Activity at the Endoplasmic Reticulum Surface Is Responsible for Augmentation of Human ether-a-go-go-related Gene Product (HERG)*},
  author={J. Sroubek and T. McDonald},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={286},
  pages={21927 - 21936}
}
  • J. Sroubek, T. McDonald
  • Published 2011
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Human ether-a-go-go-related gene product (HERG) is a cardiac potassium channel commonly implicated in the pathogenesis of the long QT syndrome, type 2 (LQT2). LQT2 mutations typically have incomplete penetrance and affect individuals at various stages of their lives; this may mirror variations in intracellular signaling and HERG regulation. Previous work showed that sustained protein kinase A (PKA) activity augments HERG protein abundance by a mechanism that includes enhanced protein… CONTINUE READING
    16 Citations
    AKAP5 anchors PKA to enhance regulation of the HERG channel.
    Role of AKAP 149-PKA-PDE4A complex in cell survival and cell differentiation processes.
    • 15
    KCNE Regulation of K+ Channel Trafficking – a Sisyphean Task?
    • 25
    Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases.
    • 47

    References

    SHOWING 1-10 OF 62 REFERENCES
    PKA phosphorylation of HERG protein regulates the rate of channel synthesis.
    • 33
    • PDF
    C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.
    • 44
    • PDF
    Correction of Defective Protein Trafficking of a Mutant HERG Potassium Channel in Human Long QT Syndrome
    • 280
    • PDF