Protein Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the Complex in Modulating ERGIC-53 Trafficking*

  title={Protein Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the Complex in Modulating ERGIC-53 Trafficking*},
  author={D. Haines and J. E. Lee and S. Beauparlant and D. B. Kyle and Willem den Besten and Michael J. Sweredoski and Robert L. J. Graham and S. Hess and R. Deshaies},
  journal={Molecular & Cellular Proteomics},
  • D. Haines, J. E. Lee, +6 authors R. Deshaies
  • Published 2012
  • Biology, Medicine
  • Molecular & Cellular Proteomics
  • UBXD1 is a member of the poorly understood subfamily of p97 adaptors that do not harbor a ubiquitin association domain or bind ubiquitin-modified proteins. Of clinical importance, p97 mutants found in familial neurodegenerative conditions Inclusion Body Myopathy Paget's disease of the bone and/or Frontotemporal Dementia and Amyotrophic Lateral Sclerosis are defective at interacting with UBXD1, indicating that functions regulated by a p97-UBXD1 complex are altered in these diseases. We have… CONTINUE READING
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