Protein Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the Complex in Modulating ERGIC-53 Trafficking*

@article{Haines2012ProteinIP,
  title={Protein Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the Complex in Modulating ERGIC-53 Trafficking*},
  author={D. Haines and J. E. Lee and S. Beauparlant and D. B. Kyle and Willem den Besten and Michael J. Sweredoski and Robert L. J. Graham and S. Hess and R. Deshaies},
  journal={Molecular & Cellular Proteomics},
  year={2012},
  volume={11}
}
  • D. Haines, J. E. Lee, +6 authors R. Deshaies
  • Published 2012
  • Biology, Medicine
  • Molecular & Cellular Proteomics
    • UBXD1 is a member of the poorly understood subfamily of p97 adaptors that do not harbor a ubiquitin association domain or bind ubiquitin-modified proteins. Of clinical importance, p97 mutants found in familial neurodegenerative conditions Inclusion Body Myopathy Paget's disease of the bone and/or Frontotemporal Dementia and Amyotrophic Lateral Sclerosis are defective at interacting with UBXD1, indicating that functions regulated by a p97-UBXD1 complex are altered in these diseases. We have… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Ubxd1 is a novel co-factor of the human p97 ATPase.
    • 42
    Insights into adaptor binding to the AAA protein p97.
    • 116
    • PDF
    UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover
    • 254
    Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4
    • 351
    Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations
    • 159
    • Highly Influential
    • PDF
    Imbalances in p97 co‐factor interactions in human proteinopathy
    • 82
    • PDF
    VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
    • 350
    The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
    • 158
    Cdc48p(Npl4p/Ufd1p) binds and segregates membrane-anchored/tethered complexes via a polyubiquitin signal present on the anchors.
    • 89
    UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97
    • 228
    • PDF