Protein Interaction Networks by Proteome Peptide Scanning

  title={Protein Interaction Networks by Proteome Peptide Scanning},
  author={Christiane Landgraf and S. Panni and Luisa Montecchi-Palazzi and Luisa Castagnoli and Jens Schneider-Mergener and Rudolf Volkmer-Engert and Gianni Cesareni},
  booktitle={PLoS biology},
A substantial proportion of protein interactions relies on small domains binding to short peptides in the partner proteins. Many of these interactions are relatively low affinity and transient, and they impact on signal transduction. However, neither the number of potential interactions mediated by each domain nor the degree of promiscuity at a whole proteome level has been investigated. We have used a combination of phage display and SPOT synthesis to discover all the peptides in the yeast… CONTINUE READING

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