Protein Fragments: Functional and Structural Roles of Their Coevolution Networks

Abstract

Small protein fragments, and not just residues, can be used as basic building blocks to reconstruct networks of coevolved amino acids in proteins. Fragments often enter in physical contact one with the other and play a major biological role in the protein. The nature of these interactions might be multiple and spans beyond binding specificity, allosteric… (More)
DOI: 10.1371/journal.pone.0048124

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