Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

@inproceedings{Stefani2013ProteinFA,
  title={Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds},
  author={Massimo Stefani and Stefania Rigacci},
  booktitle={International journal of molecular sciences},
  year={2013}
}
Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils display different toxicity. Consequently, compounds counteracting amyloid aggregation have been investigated for their ability (i) to stabilize toxic amyloid precursors; (ii) to prevent the growth of toxic oligomers or speed that of fibrils; (iii) to inhibit fibril growth and deposition; (iv) to disassemble preformed… CONTINUE READING

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