• Corpus ID: 82075798

Protein Folding: Deciphering the Second Half of the Genetic Code

  title={Protein Folding: Deciphering the Second Half of the Genetic Code},
  author={Lila M. Gierasch and Jonathan King},
Every day there are new information sources that can complicate your search for up-to-the-minute data. That's why BRS Colleague is so vital to today's biomedical professional. Colleague is a complete, online information service that compiles the world's key biomedical data and presents it in a format that's both simple and efficient to search. The Comprehensive Core Medical Library (CCML) database is the cornerstone of Colleague. The CCML contains the full text of more than 20 textbooks and… 

Predicting polypeptide and protein structures from amino acid sequence: Antlion method applied to melittin

This more demanding pilot study provides evidence that the antlion method is capable of dramatically simplifying the surface of polypeptides by successfully predicting the native form of the naturally occurring 26‐residuepolypeptide melittin.

Automated motif discovery in protein structure prediction

This thesis presents PSP as a combinatorial optimization problem, and presents and analyze a fast procedure, based on multinomial sampling and a novel coding scheme, that avoids the exhaustive search, prior limits on the order k, and exponentially large parameter space of other methods.

Optimal neural networks for protein-structure prediction.

  • Head-GordonStillinger
  • Computer Science
    Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
  • 1993
A simplified polypeptide model residing in two dimensions with only two amino-acid types is presented, which allows the determination of the global energy structure for all possible sequences of pentamer, hexamer, and heptamer lengths and shows sufficient chemical complexity so that transfer of neural-network technology to more realistic three-dimensional proteins is evident.

Concepts and techniques in molecular biology--an overview.

  • W. Sheffield
  • Biology, Chemistry
    Transfusion medicine reviews
  • 1997
This article will provide an overview aimed at demystifying these now widely used approaches to molecular biology, as a discipline lying at the confluence of biochemistry, genetics, microbiology, and protein chemistry.

The Human Genome Project: Has Blind Reductionism Gone too Far?

The Human Genome Project (HGP) is now well under way. An internationally coordinated effort, its ultimate aim is to sequence the entire human genome, producing a string of As, Ts, Gs, and Cs that

Back to the Future: Nuclear Magnetic Resonance and Bioinformatics Studies on Intrinsically Disordered Proteins.

The goal is to recount some of this history and to project from this experience possible directions for future work on intrinsically disordered proteins (IDPs) and IDP regions.

The Performance of a Lifetime: A Metaphor for the Phenotype

  • J. Lewis
  • Biology
    Perspectives in biology and medicine
  • 1999
In spilling over this boundary, the gene has brought with it the simple metaphors that have characterized molecular biology for decades, and these metaphors can be very powerful; however, if taken too literally they can lead to a highly distorted view of the relationship between genotype and phenotype, which seems to be happening in popular discussions of the role of the genome.

Prédiction structurale de biomolécules à l'aide d'une construction d'automates cellulaires simulant la dynamique moléculaire

The results prove that it is possible to predict secondary structures of RNA molecules by a simple dynamics of self-organization by using cellular automata to simulate the molecular dynamics of RNA.

Structural and molecular properties of dipeptides containing N-terminal selenomethionine: a theoretical study

  • G. Das
  • Chemistry
    Structural Chemistry
  • 2013
Although the genetic code encodes only 22 amino acids during protein bio-synthesis, there are more than 140 natural amino acids whose incorporation into the protein structures is vital for proper

Disaggregases, molecular chaperones that resolubilize protein aggregates.

This review aims to describe the characteristics of disaggregases and to discuss the function of yeast Hsp104, a disaggregase that is also involved in prion propagation and inheritance.



Unusual topogenic sequence directs prion protein biogenesis.

System-dependent topology conferred by addition of RRL to WG translation products suggests that this sequence interacts with one or more cytosolic factors.

Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving.

Analysis of the DNA cleavage patterns for dimers of the Fe.EDTA-proteins corresponding to GCN4 residues 222 to 281 and 226 to 281 revealed that the NH2-termini were in the major groove nine to ten base pairs apart and were symmetrically displaced four to five base pairs from the central C of the recognition site.

Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A.

The three-dimensional structures of an antibody to a peptide and its complex with the peptide antigen have been determined and enable a comparison of a specific monoclonal Fab' both in its free and antigen complexed state.

Functional domains and upstream activation properties of cloned human TATA binding protein.

The results indicate the importance of the NH2-terminal region for upstream activation functions and suggest that additional factors (co-activators) are required for mediating interactions with specific regulators.

Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.

Recombinant p67 (r-p67) partially restored NADPH oxidase activity to p67-deficient neutrophil cytosol from patients with chronic granulomatous diseases, suggesting the possibility of common regulatory features.

Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis.

It was concluded that phosphorylation is the signal that directs the pIgR from the endosome into the transcytotic pathway.

A cytosolic protein catalyzes the release of GDP from p21ras.

A Ras-guanine nucleotide-releasing factor, or Ras-GRF, which appears to possess a molecular size between 100,000 and 160,000 daltons is discovered in rat brain cytosol and may be involved in the activation of p21ras.

Partial symmetrization of the photosynthetic reaction center.

In an attempt to identify nonhomologous residues that are responsible for functional differences between the two branches, homologous helical regions that interact extensively with the pigments were genetically symmetrized.

A 49-kilodalton phosphoprotein in the Drosophila photoreceptor is an arrestin homolog.

The phosphorylation of this arrestin-like protein in vivo may be triggered by a Ca2+ signal that is likely to be regulated by light-activated phosphoinositide-specific phospholipase C.

A novel nucleoprotein complex at a replication origin.

Deoxyribonuclease I and hydroxyl radical footprinting data, as well as the induction of positive supercoiling, support a model in which a DNA right-handed superhelix tightly wraps around a multimeric p6 core.