Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli.

@article{Bergler1994ProteinEI,
  title={Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli.},
  author={Helmut Bergler and Peter Wallner and Anne Ebeling and Birgit Leitinger and Sandra Fuchsbichler and Heinrich Aschauer and Gert Kollenz and Gregor H{\"o}genauer and Friederike Turnowsky},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 8},
  pages={5493-6}
}
The EnvM protein was purified from an overproducing Escherichia coli strain. It showed NADH-dependent enoyl-acyl carrier protein (ACP) reductase activity using both crotonyl-ACP and crotonyl-CoA as substrates. The protein bound a radioactive diazaborine derivative in the presence of NAD+ and radioactive NAD+ in the presence of the drug. Based on these data, it is concluded that EnvM is the NADH-dependent enoyl-ACP reductase (EC 1.3.1.9) of E. coli and we propose to rename the corresponding gene… CONTINUE READING

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