Protein Dynamics in Individual Human Cells: Experiment and Theory

@article{Cohen2009ProteinDI,
  title={Protein Dynamics in Individual Human Cells: Experiment and Theory},
  author={Ariel A. Cohen and Tomer Kalisky and A. Mayo and Naama Geva-Zatorsky and Tamar Danon and Irina Issaeva and Ronen Benjamine Kopito and Natalie Perzov and Ron Milo and Alex Sigal and Uri Alon},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={3468 - 3475}
}
A current challenge in biology is to understand the dynamics of protein circuits in living human cells. Can one define and test equations for the dynamics and variability of a protein over time? Here, we address this experimentally and theoretically, by means of accurate time-resolved measurements of endogenously tagged proteins in individual human cells. As a model system, we choose three stable proteins displaying cell-cycle-dependant dynamics. We find that protein accumulation with time per… CONTINUE READING
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