Protein Domains of Unknown Function Are Essential in Bacteria

@inproceedings{Goodacre2013ProteinDO,
  title={Protein Domains of Unknown Function Are Essential in Bacteria},
  author={Norman F. Goodacre and Dietlind L. Gerloff and Peter Uetz},
  booktitle={mBio},
  year={2013}
}
UNLABELLED More than 20% of all protein domains are currently annotated as "domains of unknown function" (DUFs). About 2,700 DUFs are found in bacteria compared with just over 1,500 in eukaryotes. Over 800 DUFs are shared between bacteria and eukaryotes, and about 300 of these are also present in archaea. A total of 2,786 bacterial Pfam domains even occur in animals, including 320 DUFs. Evolutionary conservation suggests that many of these DUFs are important. Here we show that 355 essential… CONTINUE READING
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