Protein Disulfide Isomerase Regulates Endoplasmic Reticulum Stress and the Apoptotic Process during Prion Infection and PrP Mutant-Induced Cytotoxicity

@inproceedings{Wang2012ProteinDI,
  title={Protein Disulfide Isomerase Regulates Endoplasmic Reticulum Stress and the Apoptotic Process during Prion Infection and PrP Mutant-Induced Cytotoxicity},
  author={Shao-bin Wang and Qi Shi and Yin Xu and Wu-ling Xie and Jin Zhang and Chan Tian and Yan Guo and Ke Wang and Bao-yun Zhang and Cao Chen and Chen Ni Gao and Xiao-ping Dong},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Protein disulfide isomerase (PDI), is sorted to be enzymatic chaperone for reconstructing misfolded protein in endoplasmic reticulum lumen. Recently, PDI has been identified as a link between misfolded protein and neuron apoptosis. However, the potential for PDI to be involved in the pathogenesis of prion disease remains unknown. In this study, we propose that PDI may function as a pleiotropic regulator in the cytotoxicity induced by mutated prion proteins and in the pathogenesis of… CONTINUE READING
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