Protein Deposition from Dry Powder Inhalers: Fine Particle Multiplets as Performance Modifiers

@article{Lucas1998ProteinDF,
  title={Protein Deposition from Dry Powder Inhalers: Fine Particle Multiplets as Performance Modifiers},
  author={Paul Lucas and Kerry Anderson and John Nicholas Staniforth},
  journal={Pharmaceutical Research},
  year={1998},
  volume={15},
  pages={562-569}
}
AbstractPurpose. To evaluate the use of carrier-based dry powder aerosols for inhalation delivery of proteins and examine the effect of fine particle excipients as potential formulation performance modifiers. Methods. Bovine serum albumin (BSA) was co-processed with malto-dextrin by spray-drying to produce model protein particles. Aerosol formulations were prepared by tumble mixing protein powders with α-lactose monohydrate (63−90 μm) or modified lactoses containing between 2.5 and 10% w/w fine… CONTINUE READING

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Modeling the performance of carrier‐based dry powder inhalation formulations: Where are we, and how to get there?

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  • 2018
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