Protein Delivery to Vacuole Requires SAND Protein-Dependent Rab GTPase Conversion for MVB-Vacuole Fusion

@article{Singh2014ProteinDT,
  title={Protein Delivery to Vacuole Requires SAND Protein-Dependent Rab GTPase Conversion for MVB-Vacuole Fusion},
  author={Manoj Kumar Singh and Falco Krueger and Hauke Beckmann and Sabine Brumm and Joop E.M. Vermeer and Teun Munnik and Ulrike Mayer and York-Dieter Stierhof and Christopher Grefen and Karin Schumacher and Gerd J{\"u}rgens},
  journal={Current Biology},
  year={2014},
  volume={24},
  pages={1383-1389}
}
Plasma-membrane proteins such as ligand-binding receptor kinases, ion channels, or nutrient transporters are turned over by targeting to a lytic compartment--lysosome or vacuole--for degradation. After their internalization, these proteins arrive at an early endosome, which then matures into a late endosome with intraluminal vesicles (multivesicular body, MVB) before fusing with the lysosome/vacuole in animals or yeast. The endosomal maturation step involves a SAND family protein mediating Rab5… CONTINUE READING
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