Protein-DNA interactions: A structural analysis.

  title={Protein-DNA interactions: A structural analysis.},
  author={Sheila J. Jones and P van Heyningen and Helen M. Berman and Janet M. Thornton},
  journal={Journal of molecular biology},
  volume={287 5},
A detailed analysis of the DNA-binding sites of 26 proteins is presented using data from the Nucleic Acid Database (NDB) and the Protein Data Bank (PDB). Chemical and physical properties of the protein-DNA interface, such as polarity, size, shape, and packing, were analysed. The DNA-binding sites shared common features, comprising many discontinuous sequence segments forming hydrophilic surfaces capable of direct and water-mediated hydrogen bonds. These interface sites were compared to those of… CONTINUE READING
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Protein–DNA interactions: a structural analysis

  • S. Jones, P. van Heyningen, H. M. Berman, J. M. Thornton
  • J. Mol. Biol.,
  • 1999
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  • S. C. Agalarov, G. S. Prasad, P. M. Funke, C. D. Stout, J. R. Williamson
  • Science
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