Protein-DNA charge transport: redox activation of a DNA repair protein by guanine radical.

@article{Yavin2005ProteinDNACT,
  title={Protein-DNA charge transport: redox activation of a DNA repair protein by guanine radical.},
  author={Eylon Yavin and Amie K Boal and Eric D. A. Stemp and Elizabeth M Boon and Alison L. Livingston and Valerie L O'shea and Sheila S David and Jacqueline K Barton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 10},
  pages={3546-51}
}
DNA charge transport (CT) chemistry provides a route to carry out oxidative DNA damage from a distance in a reaction that is sensitive to DNA mismatches and lesions. Here, DNA-mediated CT also leads to oxidation of a DNA-bound base excision repair enzyme, MutY. DNA-bound Ru(III), generated through a flash/quench technique, is found to promote oxidation of the [4Fe-4S](2+) cluster of MutY to [4Fe-4S](3+) and its decomposition product [3Fe-4S](1+). Flash/quench experiments monitored by EPR… CONTINUE READING

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Ch Em Is Tr Y Bi O Ch Em Is Tr Y Sp Ec Ia L Fe a Tu Re

S. Steenken, S. V. Jovanovic
J. Am. Chem • 1997

Molecular Cloning: A Laboratory Manual (Cold

J. Sambrook, E. F. Fritsch, T. Maniatis
1989

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