Protein Crowding within the Postsynaptic Density Can Impede the Escape of Membrane Proteins.

@article{Li2016ProteinCW,
  title={Protein Crowding within the Postsynaptic Density Can Impede the Escape of Membrane Proteins.},
  author={Tuo P. Li and Yu Song and Harold D MacGillavry and Thomas A. Blanpied and Sridhar Raghavachari},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2016},
  volume={36 15},
  pages={4276-95}
}
UNLABELLED Mechanisms regulating lateral diffusion and positioning of glutamate receptors within the postsynaptic density (PSD) determine excitatory synaptic strength. Scaffold proteins in the PSD are abundant receptor binding partners, yet electron microscopy suggests that the PSD is highly crowded, potentially restricting the diffusion of receptors regardless of binding. However, the contribution of macromolecular crowding to receptor retention remains poorly understood. We combined… CONTINUE READING
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