Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant.

@article{Petersen2015ProteinCS,
  title={Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant.},
  author={Jens E. V. Petersen and Eveline A. M. Bouwens and I. Mart{\'i}n Tamayo and Louise Turner and Christian W Wang and Monique Stins and Thor G. Theander and Jos{\'e} Ram{\'o}n Fern{\'a}ndez Hermida and Laurent O Mosnier and Thomas Lavstsen},
  journal={Thrombosis and haemostasis},
  year={2015},
  volume={114 5},
  pages={
          1038-48
        }
}
The Endothelial Protein C receptor (EPCR) is essential for the anticoagulant and cytoprotective functions of the Protein C (PC) system. Selected variants of the malaria parasite protein, Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) associated with severe malaria, including cerebral malaria, specifically target EPCR on vascular endothelial cells. Here, we examine the cellular response to PfEMP1 engagement to elucidate its role in malaria pathogenesis. Binding of the CIDRα1.1… CONTINUE READING
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