Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

@article{Taylor1987ProteinCP,
  title={Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.},
  author={Fletcher B. Taylor and Annisa Chang and Charles T. Esmon and Antonietta D'Angelo and S Vigan{\'o}-D'Angelo and Kenneth E. Blick},
  journal={The Journal of clinical investigation},
  year={1987},
  volume={79 3},
  pages={918-25}
}
Gram-negative septicemia elicits multiple abnormalities of the coagulation system. Although products of coagulation can lead to clot formation, thereby potentiating organ damage, recent work has shown that low concentrations of thrombin can protect animals from the shock state. Because these amounts of thrombin also lead to formation in vivo of the anticoagulant enzyme, activated protein C, we examined the role of protein C in modulation of Escherichia coli shock in baboons. First, we infused… CONTINUE READING

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Bleeding Disorders: Investigation and Management

  • G.I.C. Ingram
  • Second ed. Blackwell Scientific Publications,
  • 1982
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