Protein C inhibitor. Purification from human plasma and characterization.

  title={Protein C inhibitor. Purification from human plasma and characterization.},
  author={Kiyoshi Suzuki and Junji Nishioka and Shigeru Hashimoto},
  journal={The Journal of biological chemistry},
  volume={258 1},
Protein C inhibitor was isolated from human plasma using conventional chromatographic technique consisting of barium citrate adsorption, polyethylene glycol fractionation, DEAE-Sepharose CL-6B treatment, ammonium sulfate fractionation, dextran sulfate-agarose chromatography, gel filtration on ACA-44, and DEAE-Sephacel chromatography. The purified protein C inhibitor is a single polypeptide chain with an apparent Mr = 57,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The… CONTINUE READING


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