Protein Binding of β-Lactam Antibiotics in Critically Ill Patients: Can We Successfully Predict Unbound Concentrations?

@article{Wong2013ProteinBO,
  title={Protein Binding of $\beta$-Lactam Antibiotics in Critically Ill Patients: Can We Successfully Predict Unbound Concentrations?},
  author={Gloria Wong and Scott E Briscoe and Syamhanin Adnan and Brett C McWhinney and Jacobus P J Ungerer and Jeffrey Lipman and Jason Alexander Roberts},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2013},
  volume={57},
  pages={6165 - 6170}
}
ABSTRACT The use of therapeutic drug monitoring (TDM) to optimize beta-lactam dosing in critically ill patients is growing in popularity, although there are limited data describing the potential impact of altered protein binding on achievement of target concentrations. The aim of this study was to compare the measured unbound concentration to the unbound concentration predicted from published protein binding values for seven beta-lactams using data from blood samples obtained from critically… Expand
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