Protein Architecture of the Human Kinetochore Microtubule Attachment Site

@article{Wan2009ProteinAO,
  title={Protein Architecture of the Human Kinetochore Microtubule Attachment Site},
  author={Xiaohu Wan and R P O'quinn and Heather L. Pierce and Ajit P. Joglekar and Walt E. Gall and Jennifer G DeLuca and Christopher W Carroll and Song-Tao Liu and Tim J. Yen and Bruce F. McEwen and P. Todd Stukenberg and Arshad Desai and Edward Dickinson Salmon},
  journal={Cell},
  year={2009},
  volume={137},
  pages={672-684}
}
Chromosome segregation requires assembly of kinetochores on centromeric chromatin to mediate interactions with spindle microtubules and control cell-cycle progression. To elucidate the protein architecture of human kinetochores, we developed a two-color fluorescence light microscopy method that measures average label separation, Delta, at <5 nm accuracy. Delta analysis of 16 proteins representing core structural complexes spanning the centromeric chromatin-microtubule interface, when correlated… CONTINUE READING
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