Protein ADP-ribosylation and the cellular response to DNA strand breaks.

Abstract

DNA strand breaks arise continuously in cells and can lead to chromosome rearrangements and genome instability or cell death. The commonest DNA breaks are DNA single-strand breaks, which arise at a frequency of tens-of-thousands per cell each day and which can block the progression of RNA/DNA polymerases and disrupt gene transcription and genome duplication… (More)
DOI: 10.1016/j.dnarep.2014.03.021

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