Protein A-mediated multicellular behavior in Staphylococcus aureus.

  title={Protein A-mediated multicellular behavior in Staphylococcus aureus.},
  author={Nekane Merino and Alejandro Toledo-Arana and Marta Vergara-Irigaray and Jaione Valle and Cristina Solano and Enrique Calvo and Juan A L{\'o}pez and T. J. Foster and Jos{\'e} R Penad{\'e}s and I{\~n}igo Lasa},
  journal={Journal of bacteriology},
  volume={191 3},
The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells are encased in a biofilm often consists of the polysaccharide intercellular adhesin (PIA) or poly-N-acetyl glucosamine (PNAG). However, surface proteins capable of promoting biofilm development in the absence of PIA/PNAG exopolysaccharide have been described. Here, we used two… CONTINUE READING
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  • K. M. Brothers, R. M. Martinez, N. P. Donegan, M. L. Graber, A. L. Cheung, G. A. O’Toole
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