Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane.

@article{Salomao2008Protein4M,
  title={Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane.},
  author={Marcela A Salomao and Xihui Zhang and Yang Yang and Soohee Lee and John H. Hartwig and Joel Anne Chasis and Narla Mohandas and Xiuli An},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 23},
  pages={8026-31}
}
Protein 4.1R (4.1R) is a multifunctional component of the red cell membrane. It forms a ternary complex with actin and spectrin, which defines the nodal junctions of the membrane-skeletal network, and its attachment to the transmembrane protein glycophorin C creates a bridge between the protein network and the membrane bilayer. We now show that deletion of 4.1R in mouse red cells leads to a large diminution of actin accompanied by extensive loss of cytoskeletal lattice structure, with formation… CONTINUE READING

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