Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation

@article{Kuns2005Protein4E,
  title={Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation},
  author={Robin Kuns and Joseph L Kissil and Irene F. Newsham and Tyler 8 Jacks and David H Gutmann and Larry S. Sherman},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={6502-6515}
}
4.1B is a member of the protein 4.1 superfamily of proteins that link transmembrane proteins to the actin cytoskeleton. The 4.1B gene localizes to chromosome 18p11.3, which undergoes loss of heterozygosity in mammary tumors. Here, we examine the expression of 4.1B in murine mammary epithelium and find that 4.1B is dramatically upregulated in mammary epithelial cells during pregnancy when there is extensive cell proliferation. In contrast, 4.1B is not expressed in virgin, lactating, or… CONTINUE READING

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Epithelial CellsIs normal cell origin of diseaseBreast Carcinoma
Collectively , our findings demonstrate that 4.1B regulates mammary epithelial cell proliferation during pregnancy and suggest that its loss may influence mammary carcinoma pathogenesis in multiparous women .
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