Protein 3 Gene Variant , Vascular Function , and Insulin Sensitivity in Type 2 Diabetes

@inproceedings{FernndezReal2002Protein3G,
  title={Protein 3 Gene Variant , Vascular Function , and Insulin Sensitivity in Type 2 Diabetes},
  author={Jos{\'e} Fern{\'a}ndez-Real and Georgina Pe{\~n}arroja and Crist{\'o}bal Richart and Antoni Castro and Joan Vendrell and Montserrat Broch and Abel L{\'o}pez-Bermejo and Wifredo Ricart},
  year={2002}
}
A common polymorphism (825 C/T) in exon 10 of the GNB3 gene, that encodes for the -3 subunit, has been associated with different degrees of activation of heterotrimeric guanine nucleotide binding proteins (G proteins). Many hormones and neurotransmitters use specific receptors that interact noncovalently with G proteins in the transmembrane signaling process. Among them, insulin uses an inhibitory G protein–sensitive mechanism that is involved in metabolic and vascular events, leading to… CONTINUE READING
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