Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway.

@article{Kino2003Protein1I,
  title={Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway.},
  author={Tomoshige Kino and Emanuel Souvatzoglou and Massimo De Martino and Maria Tsopanomihalu and Yihong Wan and George P. Chrousos},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 28},
  pages={25651-6}
}
The glucocorticoid receptor (GR) alpha interacts with the highly conserved 14-3-3 family proteins. The latter bind phosphorylated serine/threonine residues of "partner" molecules and influence many signal transduction events by altering their subcellular localization and/or protecting them from proteolysis. To examine the physiologic role of 14-3-3 on the glucocorticoid-signaling pathway, we studied the nucleocytoplasmic shuttling and transactivation properties of GRalpha in a cell line replete… CONTINUE READING

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