Protein–Protein interactions, cytoskeletal regulation and neuronal migration

@article{Feng2001ProteinProteinIC,
  title={Protein–Protein interactions, cytoskeletal regulation and neuronal migration},
  author={Yuanyi Feng and Christopher A. Walsh},
  journal={Nature Reviews Neuroscience},
  year={2001},
  volume={2},
  pages={408-416}
}
Neuronal migration, like the migration of many cell types, requires an extensive rearrangement of cell shape, mediated by changes in the cytoskeleton. The genetic analysis of human brain malformations has identified several biochemical players in this process, including doublecortin (DCX) and LIS1, mutations of which cause a profound migratory disturbance known as lissencephaly ('smooth brain') in humans. Studies in mice have identified additional molecules such as Cdk5, P35, Reelin, Disabled… 

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