Protein–Protein Interactions in Multienzyme Megasynthetases

@article{Weissman2008ProteinProteinII,
  title={Protein–Protein Interactions in Multienzyme Megasynthetases},
  author={K. Weissman and R. M{\"u}ller},
  journal={ChemBioChem},
  year={2008},
  volume={9}
}
The multienzyme polyketide synthases (PKSs), nonribosomal polypeptide synthetases (NRPSs), and their hybrids are responsible for the construction in bacteria of numerous natural products of clinical value. These systems generate high structural complexity by using a simple biosynthetic logic—that of the assembly line. Each of the individual steps in building the metabolites is designated to an independently folded domain within gigantic polypeptides. The domains are clustered into functional… Expand
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