Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks

@inproceedings{Rivas2010ProteinProteinIE,
  title={Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks},
  author={Javier De Las Rivas and Celia Fontanillo},
  booktitle={PLoS Computational Biology},
  year={2010}
}
Decades of research into cell biology, molecular biology, biochemistry, structural biology, and biophysics have produced a remarkable compendium of knowledge on the function and molecular properties of individual proteins. This knowledge is well recorded and manually curated into major protein databases like UniProt [1,2]. However, proteins rarely act alone. Many times they team up into ‘‘molecular machines’’ and have intricate physicochemical dynamic connections to undertake biological… CONTINUE READING
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