Protein‐spanning water networks and implications for prediction of protein–protein interactions mediated through hydrophobic effects

@article{Cui2014ProteinspanningWN,
  title={Protein‐spanning water networks and implications for prediction of protein–protein interactions mediated through hydrophobic effects},
  author={Di Cui and Shuching Ou and Sandeep Patel},
  journal={Proteins: Structure},
  year={2014},
  volume={82}
}
Hydrophobic effects, often conflated with hydrophobic forces, are implicated as major determinants in biological association and self‐assembly processes. Protein–protein interactions involved in signaling pathways in living systems are a prime example where hydrophobic effects have profound implications. In the context of protein–protein interactions, a priori knowledge of relevant binding interfaces (i.e., clusters of residues involved directly with binding interactions) is difficult. In the… 
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