Protein‐misfolding diseases and chaperone‐based therapeutic approaches

  title={Protein‐misfolding diseases and chaperone‐based therapeutic approaches},
  author={T. K. Chaudhuri and S. Paul},
  journal={The FEBS Journal},
  • T. K. Chaudhuri, S. Paul
  • Published 2006
  • Biology, Medicine
  • The FEBS Journal
  • A large number of neurodegenerative diseases in humans result from protein misfolding and aggregation. Protein misfolding is believed to be the primary cause of Alzheimer's disease, Parkinson's disease, Huntington's disease, Creutzfeldt–Jakob disease, cystic fibrosis, Gaucher's disease and many other degenerative and neurodegenerative disorders. Cellular molecular chaperones, which are ubiquitous, stress‐induced proteins, and newly found chemical and pharmacological chaperones have been found… CONTINUE READING
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