Protegrins: new antibiotics of mammalian origin.

  title={Protegrins: new antibiotics of mammalian origin.},
  author={Lisa Bellm and Robert I. Lehrer and Tomas Ganz},
  journal={Expert opinion on investigational drugs},
  volume={9 8},
Protegrins and their derivatives are a new class of peptide antibiotics based on mammalian antimicrobial peptides. Their pharmacological properties include an unusually broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi and some enveloped viruses. Preclinical and clinical studies of the lead compound, IB-367, developed for topical applications, show promise for the prevention of chemotherapy- and radiation-induced oral mucositis. 

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