Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response.

@article{Handman1995ProtectiveVW,
  title={Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response.},
  author={Emanuela Handman and Fr. Symons and Tracey M. Baldwin and Joan M. Curtis and Jean Pierre Y Scheerlinck},
  journal={Infection and immunity},
  year={1995},
  volume={63 11},
  pages={
          4261-7
        }
}
Leishmania major promastigote surface antigen-2 complex (PSA-2) comprises a family of three similar but distinct polypeptides. The three PSA-2 polypeptides were purified from cultured promastigotes by a combination of detergent phase separation and monoclonal antibody affinity chromatography. Intraperitoneal vaccination of C3H/He mice with PSA-2 with Corynebacterium parvum as an adjuvant resulted in complete protection from lesion development after challenge infection with virulent L. major… CONTINUE READING
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