Protective upregulation of activating transcription factor-3 against glutamate neurotoxicity in neuronal cells under ischemia.

Abstract

This study evaluates the pathological role of the stress sensor activating transcription factor-3 (ATF3) in ischemic neurotoxicity. Upregulation of the transcript and protein for ATF3 was seen 2-10 hr after reperfusion in the ipsilateral cerebral hemisphere of mice with transient middle cerebral artery occlusion for 2 hr. Immunohistochemical analysis… (More)
DOI: 10.1002/jnr.23723

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