Protective roles of endogenous carbon monoxide in neointimal development elicited by arterial injury.

@article{Togane2000ProtectiveRO,
  title={Protective roles of endogenous carbon monoxide in neointimal development elicited by arterial injury.},
  author={Yuko Togane and Toshihiro Morita and Makoto Suematsu and Yuzuru Ishimura and Junya Yamazaki and Shigeru Katayama},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 2},
  pages={
          H623-32
        }
}
We reported that carbon monoxide (CO) generated through heme oxygenase (HO) inhibits mitogen-induced proliferation of vascular smooth muscle cells (VSMCs). We report that balloon injury induces HO-1, the stress-inducible isozyme of HO, in VSMCs and inhibits neointimal formation through the action of endogenous CO. Northern blot analysis and immunohistochemistry revealed that HO-1 is markedly induced in the media as early as 1 day after injury, whereas only a little expression was detected in… CONTINUE READING

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Heme Oxygenases in Cardiovascular Health and Disease.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1995
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Distribution of heme oxygenase isozymes in rat liver

N. Goda, K K.Suzuki., +5 authors M. Suematsu
  • J. Clin. Invest
  • 1998
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Isolation and characterization of a CDNA from the rat brain that encodes hemoprotein heme oxygenase-3

W. K. McCoubrey, Jr., T. J. Huang, M. D. Maines
  • Eur. J. Biochem
  • 1997
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Endothelin and endothelin-converting enzyme expression at the site of percutaneus transluminal coronary angioplasty in humans (Abstract)

T. Naruko, K. Ueda, +4 authors A. E. Becker
  • Circulation 96:
  • 1997
VIEW 3 EXCERPTS