Protective role of the virus-specific immune response for development of severe neurologic signs in simian immunodeficiency virus-infected macaques.

@article{Sopper1998ProtectiveRO,
  title={Protective role of the virus-specific immune response for development of severe neurologic signs in simian immunodeficiency virus-infected macaques.},
  author={Sieghart Sopper and Ursula S Sauer and Simone Hemm and Monika Demuth and Justus G Mueller and Christiane Stahl-Hennig and Gerhard Hunsmann and Volker Ter Meulen and Ruediger Doerries},
  journal={Journal of virology},
  year={1998},
  volume={72 12},
  pages={
          9940-7
        }
}
The pathogenesis of human immunodeficiency virus-associated motor and cognitive disorders is poorly understood. In this context both a protective and a harmful role of the immune system has been discussed. This question was addressed in the present study by correlating the occurrence of neurologic disease in simian immunodeficiency virus (SIV)-infected macaques with disease progression and the humoral and cellular intrathecal antiviral immune response. Overt neurologic signs consisting of… CONTINUE READING
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