Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress

@article{Tasaki2017ProtectiveRO,
  title={Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress},
  author={Eisuke Tasaki and S Matsumoto and Hisashi Tada and Toshihiro Kurahashi and Xuhong Zhang and Junichi Fujii and Toshihiko Utsumi and Yoshihito Iuchi},
  journal={Journal of Clinical Biochemistry and Nutrition},
  year={2017},
  volume={60},
  pages={156 - 161}
}
Peroxiredoxin (PRDX), a newly discovered antioxidant enzyme, has an important role in hydrogen peroxide reduction. Among six PRDX genes (PRDX1–6) in mammals, PRDX4 gene is alternatively spliced to produce the somatic cell form (PRDX4) and the testis specific form (PRDX4t). In our previous study, PRDX4 knockout mice displayed testicular atrophy with an increase in cell death due to oxidative stress. However, the antioxidant function of PRDX4t is unknown. In this study, we demonstrate that PRDX4t… 
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