Protective role of taurine against genotoxic damage in mice treated with methotrexate and tamoxfine.

@article{Alam2011ProtectiveRO,
  title={Protective role of taurine against genotoxic damage in mice treated with methotrexate and tamoxfine.},
  author={S. S. Alam and N. Hafiz and Abeer H. Abd El-Rahim},
  journal={Environmental toxicology and pharmacology},
  year={2011},
  volume={31 1},
  pages={
          143-52
        }
}
The genotoxic actions of anti-neoplastic drugs can lead to the development of secondary cancers in patients in extended remission. One of the most attractive approaches to disease prevention involves the use of natural antioxidants to protect tissue against toxic injury. We investigated the modulatory effects of exogenously administered taurine, on the genotoxicity of two well known anti-neoplastic drugs methotrexate (MTX) and tamoxifen (TAM) in Swiss albino mice. The animals were randomly… Expand
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