Protective role of phospholipid oxidation products in endotoxin-induced tissue damage

@article{Bochkov2002ProtectiveRO,
  title={Protective role of phospholipid oxidation products in endotoxin-induced tissue damage},
  author={Valery N. Bochkov and Alexandra Kadl and Joakim Huber and Florian Gruber and Bernd R. Binder and Norbert Leitinger},
  journal={Nature},
  year={2002},
  volume={419},
  pages={77-81}
}
Lipopolysaccharide (LPS), an outer-membrane component of Gram-negative bacteria, interacts with LPS-binding protein and CD14, which present LPS to toll-like receptor 4 (refs 1, 2), which activates inflammatory gene expression through nuclear factor κB (NFκB) and mitogen-activated protein-kinase signalling. Antibacterial defence involves activation of neutrophils that generate reactive oxygen species capable of killing bacteria; therefore host lipid peroxidation occurs, initiated by enzymes such… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 129 extracted citations

Similar Papers

Loading similar papers…