Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels.

@article{Bao2014ProtectiveRO,
  title={Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels.},
  author={Xiao-chen Bao and Yi-qun Fang and P F You and Shi Cui Zhang and Jun Ma},
  journal={Experimental lung research},
  year={2014},
  volume={40 3},
  pages={105-16}
}
Recent studies have demonstrated that peroxisome proliferator-activated receptor-beta/delta (PPAR-β/δ) has a protective effect during lung injury induced by bleomycin and polymicrobial sepsis, but its function in pulmonary oxygen toxicity is unknown. In this study, we used GW0742, a PPAR-β/δ agonist, and GSK0660, a PPAR-β/δ antagonist, to test the role of… CONTINUE READING