Protective role of palmitoylethanolamide in contact allergic dermatitis.

  title={Protective role of palmitoylethanolamide in contact allergic dermatitis.},
  author={Stefania Petrosino and Luigia Cristino and Meliha Karsak and Evelyn Gaffal and Naohiro Ueda and Thomas T{\"u}ting and Tiziana Bisogno and Daniele De Filippis and Angela D'Amico and C. Saturnino and Pierangelo Orlando and Anne Zimmer and Teresa Iuvone and Vicenzo Di Marzo},
  volume={65 6},
BACKGROUND Palmitoylethanolamide (PEA) is an anti-inflammatory mediator that enhances the activation by anandamide (AEA) of cannabinoid receptors and transient receptor potential vanilloid type-1 (TRPV1) channels, and directly activates peroxisome proliferator-activated receptor-alpha (PPAR-alpha). In mice, 2,4-dinitrofluorobenzene (DNFB)-induced contact allergic dermatitis (CAD) in inflamed ears is partly mediated by the chemokine Monocyte Chemotactic Protein-2 (MCP-2) and accompanied by… CONTINUE READING