• Corpus ID: 22593282

Protective role of magnesium in catecholamine-induced arrhythmia and toxicity in vitro.

  title={Protective role of magnesium in catecholamine-induced arrhythmia and toxicity in vitro.},
  author={Martin M. Zdanowicz and Michael A. Barletta},
  journal={Magnesium research},
  volume={4 3-4},
The present study examined the arrhythmogenic and toxic liability of isoprenaline, noradrenaline and adrenaline using a model of spontaneously beating, cultured rat cardiomyocytes. The cardioprotective role of magnesium (Mg) was also evaluated. Following two hours of exposure to 0.1-2.7 mM doses of isoprenaline, noradrenaline or adrenaline, there were dose-dependent increases in the incidence of arrhythmia and decreases in beating activity. Myocyte LDH release increased 64-189% while total… 

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