Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model

  title={Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model},
  author={Mohammad hosein Somi and Babak Hajipour and Ghader Dargahi Abbas Abad and Mohammad Reza Hemmati and Kamyar Ghabili and Ali Khodadadi and Amir Mansour Vatankhah},
  journal={Indian Journal of Gastroenterology},
Methotrexate (MTX), a folate antagonist agent, is mainly used in treatment of malignant tumors and auto immune diseases and affects not only tumor cells, but also gastrointestinal mucosa. The present study was undertaken to determine whether lipoic acid (LA) could ameliorate methotrexate-induced oxidative intestine injury in rabbits. Twenty-one rabbits were randomly assigned into three groups: Group 1 (control group), Group 2 (received 20 mg/kg MTX), Group 3 (received MTX plus LA 75 mg/kg… 

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