Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model

  title={Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model},
  author={M. H. Somi and B. Hajipour and Ghader Dargahi Abbas Abad and M. R. Hemmati and K. Ghabili and A. Khodadadi and A. M. Vatankhah},
  journal={Indian Journal of Gastroenterology},
  • M. H. Somi, B. Hajipour, +4 authors A. M. Vatankhah
  • Published 2011
  • Physics, Medicine
  • Indian Journal of Gastroenterology
  • Methotrexate (MTX), a folate antagonist agent, is mainly used in treatment of malignant tumors and auto immune diseases and affects not only tumor cells, but also gastrointestinal mucosa. The present study was undertaken to determine whether lipoic acid (LA) could ameliorate methotrexate-induced oxidative intestine injury in rabbits. Twenty-one rabbits were randomly assigned into three groups: Group 1 (control group), Group 2 (received 20 mg/kg MTX), Group 3 (received MTX plus LA 75 mg/kg… CONTINUE READING
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