Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model

@article{Somi2011ProtectiveRO,
  title={Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model},
  author={Mohammad hosein Somi and Babak Hajipour and Ghader Dargahi Abbas Abad and Mohammad Reza Hemmati and Kamyar Ghabili and Ali Khodadadi and Amir Mansour Vatankhah},
  journal={Indian Journal of Gastroenterology},
  year={2011},
  volume={30},
  pages={38-40}
}
Methotrexate (MTX), a folate antagonist agent, is mainly used in treatment of malignant tumors and auto immune diseases and affects not only tumor cells, but also gastrointestinal mucosa. The present study was undertaken to determine whether lipoic acid (LA) could ameliorate methotrexate-induced oxidative intestine injury in rabbits. Twenty-one rabbits were randomly assigned into three groups: Group 1 (control group), Group 2 (received 20 mg/kg MTX), Group 3 (received MTX plus LA 75 mg/kg… 
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14 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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14 Citations

Protective Effect of Vitamin A against Oxidative Stress Caused by Methotrexate

The present study suggests that the administration of vit.A with MTX is associated with reduction in oxidative stress, and therapeutic role in reduced toxicity of MTX.

Protective Effects of Exogenous Melatonin Against Methotrexate-Induced Intestinal Injury

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Preclinical Efficacy of Melatonin to Reduce Methotrexate-Induced Oxidative Stress and Small Intestinal Damage in Rats

The results of the present study demonstrate that supplementation by exogenous melatonin significantly reduces MTX-induced small intestinal damage, indicating that it may be beneficial in ameliorating MTx-induced enteritis in humans.

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The results concluded that methotrexate combined with barley (Hordeum vulgare L.) in comparison with metotrexate induced less intestinal mucosal damage and this protective effect might be due to the anti-inflammatory and antiulcer activity of barley.

Evaluation of the possible protective role of vitamin A on methotrexate-induced changes on the jejunal mucosa of adult male albino rat: Histological and immunohistochemical study

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It can be concluded that ALA may be a promising therapeutic option for prevention and (or) treatment of deltamethin toxicity.

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A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat

It is concluded that MTX causes acute inflammatory changes with damage to the villi and crypts of lieberkhun that may result in decreased nutrient absorption associated with barrier and absorptive dysfunction of the small intestine.

Does Erythropoietin Protect the Intestine against Ischemic / Reperfusion Injury in Rabbits ?

Erythropoietin might exert a protective effect against ischemic/reperfusion injury in the rabbit model of intestinal ischemia and Histopathological assessment revealed that Park’s score at 12 hours after the isChemic/ reperfusions injury was significantly lower in the EPO-treated group compared with the control group.

The effect of quince leaf (Cydonia oblonga miller) decoction on testes in hypercholesterolemic rabbits: a pilot study.

Quince leaf decoction (C. oblonga Miller) protected rabbit testes and spermatogenesis from damage induced by hypercholesterolemia.

14 References

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