Protective role of interleukin-10 in atherosclerosis.

@article{Mallat1999ProtectiveRO,
  title={Protective role of interleukin-10 in atherosclerosis.},
  author={Z. Mallat and S. Besnard and M. Duriez and V. Deleuze and F. Emmanuel and M. Bureau and F. Soubrier and B. Esposito and H. Duez and C. Fi{\'e}vet and B. Staels and N. Duverger and D. Scherman and A. Tedgui},
  journal={Circulation research},
  year={1999},
  volume={85 8},
  pages={
          e17-24
        }
}
The potential role of anti-inflammatory cytokines in the modulation of the atherosclerotic process remains unknown. Interleukin (IL)-10 has potent deactivating properties in macrophages and T cells and modulates many cellular processes that may interfere with the development and stability of the atherosclerotic plaque. IL-10 is expressed in human atherosclerosis and is associated with decreased signs of inflammation. In the present study, we show that IL-10-deficient C57BL/6J mice fed an… Expand
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