Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis.

  title={Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis.},
  author={Brian Ketterer},
  journal={Mutation research},
  volume={202 2},
Glutathione (GSH) alone detoxifies electrophiles with an effectiveness which depends on the rate of the reaction and the concentration of GSH. If electrophiles are substrates for GSH transferase isoenzymes, the effectiveness of detoxication is much enhanced due to the increased rate of reaction and it is also independent of GSH concentration to low levels of GSH depletion, since the Km for GSH is approximately 0.1 mM. In this paper detoxication of electrophilic metabolites of the… CONTINUE READING


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