Protective role of excitatory amino acid antagonists in experimental retinal ischemia

@article{Weber1995ProtectiveRO,
  title={Protective role of excitatory amino acid antagonists in experimental retinal ischemia},
  author={Michel Weber and Nicole Bonaventure and Jos{\'e} Alain Sahel},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={1995},
  volume={233},
  pages={360-365}
}
• Background: Excitatory amino acids and their analogues (NMDA, kainate and AMPA) are implicated in the pathogenesis of ischemic brain injury. In order to fully understand their involvement in the pathogenesis of retinal ischemic injury, we studied the electrophysiological and histopathological effects of two excitatory amino acid antagonists, cis-PDA and MK 801, in an experimental retinal ischemia model. • Methods: The two antagonists were injected intravitreously 15 min before ischemia was… CONTINUE READING
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